Publications by authors named "M Theobald"
Initial clinical trials with drugs targeting epigenetic modulators - such as bromodomain and extraterminal protein (BET) inhibitors - demonstrate modest results in acute myeloid leukemia (AML). A major reason for this involves an increased transcriptional plasticity within AML, which allows cells to escape the therapeutic pressure. In this study, we investigated immediate epigenetic and transcriptional responses following BET inhibition and could demonstrate that BET inhibitor-mediated release of BRD4 from chromatin is accompanied by an acute compensatory feedback that attenuates down-regulation, or even increases expression, of specific transcriptional modules.
View Article and Find Full Text PDFSomatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP), potentially progressing to myelodysplastic syndromes (MDS). Here, we investigated how CHIP and MDS remodel the human bone marrow (BM) niche relative to healthy elderly donors, using single cell and anatomical analyses in a large BM cohort. We found distinct inflammatory remodeling of the BM in CHIP and MDS.
View Article and Find Full Text PDFArticle Synopsis
- * Over 16,000 patients were screened, revealing a high prevalence of CI (37.8%) and a significantly higher rate of hospital-acquired complications (HACs) in those with CI, but the intervention did not lead to a significant reduction in HAC rates.
- * The results showed variations in the program’s implementation across hospitals, and despite some slight overall reductions in HAC rates, these changes were not statistically significant, suggesting the need for further refinement in intervention strategies.
Background And Aims: The hypothesis that study strategies can compensate for less study time in predicting learning outcomes has often been proposed but rarely tested empirically.
Methods: In the present study, 231 university students reported their daily perceived time spent on self-study, study strategies (planning, monitoring, concentration and procrastination) and goal achievement over a 30 days period.
Results And Conclusion: Results showed that both more overall perceived study time and better study strategies (better planning, monitoring, and concentration, less procrastination) predicted higher goal achievement at the end of the day.
Article Synopsis
- MG-PRCA is a condition where the bone marrow fails to produce enough red blood cells due to the presence of abnormal proteins from monoclonal plasma cell disorders, leading to anemia.
- Patients typically show low reticulocyte counts and have normocytic, normochromic anemia as a result.
- The case discussed highlights successful treatment using a combination of isatuximab, pomalidomide, and dexamethasone after previous treatments had failed.