Publications by authors named "M Thase"
Article Synopsis
- The study examined the predictive value of cytokine levels (MIF and IL-1β) in determining responses to antidepressant treatment in 1,299 patients as part of a larger trial.
- Despite initial findings from smaller studies indicating a link between these cytokines and treatment response, the current research found no significant associations with depression score changes or treatment outcomes.
- The lack of replication raises doubts about the usefulness of these biomarkers in clinical settings for treating depression.
Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients.
Objectives: In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients.
Article Synopsis
- The study aimed to compare the time until relapse in patients with major depressive disorder (MDD) who continued or withdrew brexpiprazole after stabilizing on antidepressants.* -
- In a Phase 3 clinical trial involving 1149 patients, those who received either continued brexpiprazole or placebo showed similar median relapse times of 63 days, with around 80% remaining relapse-free at the end of the study.* -
- The findings suggest that whether patients continued brexpiprazole or switched to a placebo, the outcomes were similar, and the treatment was generally well tolerated with minimal side effects.*
The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study were used to fit several regularised Gaussian Graphical Models. Differences in the presentation of depressive and manic symptoms were uncovered: only among participants with a history of childhood abuse, inadequacy and pessimism were central symptoms in the network of depressive symptoms, while racing thoughts was an important symptom in the network of manic symptoms.
View Article and Find Full Text PDFAll definitions of treatment-resistant depression (TRD) require that patients have experienced insufficient benefit from one or more adequate antidepressant trials. Thus, identifying "failed, adequate trials" is key to the assessment of TRD. The Antidepressant Treatment History Form (ATHF) was one of the first and most widely used instruments that provided objective criteria in making these assessments.
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