Recto Sigmoid Sub-Mucosal Bleeding Due to Warfarin over Anticoagulation Presenting as Intestinal Obstruction.

Patients on anticoagulation therapy, particularly those on warfarin, are at risk of gastrointestinal bleeding, gum bleeding, hematuria, and ecchymosis. However, it is rare for such patients to present with intramural or submucosal bleeding leading to intestinal obstructive symptoms. Sub-mucosal intestinal bleeding due to prolonged anticoagulant use is uncommon.

Global diversity in bipolar disorder: the role of cultural and social differences with a view to genomics.

As global gene discovery efforts turn away from a historic Eurocentric focus and advance towards embracing more diverse populations, consideration of sociocultural aspects of bipolar disorder become critical to their success. Diversity can be leveraged to accelerate gene discovery, via different patterns of linkage disequilibrium that lead to greater resolution of mapping association signals, and convergence of genes and pathways implicated within and across diverse ancestral groups improving our understanding of the molecular underpinnings of disease. However it is not just the differences in linkage disequilibrium structure and allele frequency that drive differences in genomic signals between populations.

Determinants of road construction project delay in the case of Woliso-Ambo road construction.

Despite delays, infrastructure development is crucial for socio-economic development and economic growth. Identifying and managing these delays increases project quality, reduces conflicts and risks, and ultimately contributes to overall development. This study summarizes the variables influencing the delay of the Woliso-Ambo Road construction project via multiple regression analysis and questionnaire surveys.

Genomics yields biological and phenotypic insights into bipolar disorder.

Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.

Transition to Piscivory Seen Through Brain Transcriptomics in a Juvenile Percid Fish: Complex Interplay of Differential Gene Transcription, Alternative Splicing, and ncRNA Activity.

Pikeperch (Sander Lucioperca) belongs to main predatory fish species in freshwater bodies throughout Europe playing the key role by reducing planktivorous fish abundance. Two size classes of the young-of-the-year (YOY) pikeperch are known in Europe and North America. Our long-term fish survey elucidates late-summer size distribution of YOY pikeperch in the Lipno Reservoir (Czechia) and recognizes two distinct subcohorts: smaller pelagic planktivores heavily outnumber larger demersal piscivores.