Publications by authors named "M Terris"
Background: Adverse pathology (AP) is often used as an intermediate end point for long-term outcomes in men with prostate cancer (PCa) who are active surveillance candidates. The association between a commonly used AP definition and long-term outcomes was tested, which identified definitions more strongly linked to a high risk of metastasis.
Methods: Data were reviewed from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing radical prostatectomy (RP) from 1988 to 2020 at nine Veterans Affairs hospitals.
Article Synopsis
- - Bladder cancer mortality rates are higher in African American (AA) patients compared to European American (EA) patients, but the reasons for this disparity are not fully understood.
- - Research using RNA-Seq, proteomics, and metabolomics shows that AA bladder cancer has increased mitochondrial oxidative phosphorylation (OXPHOS) driven by complex I activation, leading to metabolic changes that promote disease progression.
- - Targeting components of complex I and the enzyme GLS1 could be a potential therapeutic strategy, as knocking down these factors reduced tumor growth and mitochondrial activity in AA bladder cancer cells.
Importance And Objective: Partial gland ablation (PGA) is increasingly popular as a treatment for men with intermediate-risk prostate cancer (IR-PCa) to preserve functional outcomes while controlling their cancer. We aimed to determine the impact of race and clinical characteristics on the risk of upstaging (≥pT2c) and having adverse pathological outcomes including seminal vesicle invasion (SVI), extra prostatic extension (EPE) and lymph node invasion (LNI) at radical prostatectomy (RP) among men with IR disease eligible for PGA with hemi-ablation (HA).
Design: Retrospective analysis.