Publications by authors named "M Terlizzo"
Article Synopsis
- Most oesophagogastric adenocarcinomas (OGAs) and colorectal cancers (CRCs) are mismatch repair proficient, which means they typically don't respond well to immune checkpoint therapies; this study looks at combining domatinostat, a histone deacetylase inhibitor, with avelumab, an anti-PD-L1 antibody, in treating these cancers.
- The clinical trial involved a multicenter phase II study where patients received different doses of domatinostat alongside avelumab to find the best dosage and assess the treatment's effectiveness over six months.
- Results showed that in the OGA group, about 22.2% had a positive response to the treatment with a median disease control duration of 11
Article Synopsis
- This study investigates the impact of pathological lymph node (LN) regression after neoadjuvant chemotherapy on survival rates in patients with esophageal adenocarcinoma, addressing a gap in existing research and defining LN response classifications.
- Conducted across five UK centers, the study analyzed 17,930 LNs from 763 patients, assigning scores based on the extent of residual tumor found in the nodes after treatment, with survival outcomes assessed using advanced statistical methods.
- Results showed that patients with complete or partial LN response had significantly lower mortality rates compared to those with poor or no LN response, highlighting LN regression as a vital prognostic factor that should be considered alongside traditional staging methods.
Appendiceal tumours encompass a wide spectrum of differential diagnoses and frequently present with clinical features of appendicitis. We report the case of a 43-year-old woman who presented with epigastric pain, dyspepsia and bloating. An atypical right para-iliac mass was detected on abdominal ultrasound, and computed tomography (CT) identified an appendiceal tumour.
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- Gallbladder cancer has a poor prognosis, and imaging methods like FDG-PET/CT have varying levels of diagnostic accuracy for this type of cancer.
- A retrospective study included 22 patients with suspected gallbladder cancer who underwent preoperative FDG-PET/CT, comparing their histological results.
- The results showed no significant ability of FDG-PET/CT to differentiate between malignant and benign cases, indicating that this imaging method is not reliable for confirming gallbladder cancer diagnosis.