and Leishmanicidal Activity of Beauvericin.

Leishmaniasis is a worldwide disease caused by more than 20 species of parasites. and are among the main causative agents of cutaneous leishmaniasis, presenting a broad spectrum of clinical forms. As these pathologies lead to unsatisfactory treatment outcomes, the discovery of alternative chemotherapeutic options is urgently required.

Improved production of palitantin by design of experiments and semi-synthesis of palitantin derivatives for bioactivity assessment.

A new method for the production and isolation of (+)-palitantin (1) is herein reported, from cultures of the fungal strain Penicillium sp. AMF1a. (+)-Palitantin was isolated in 160 mg/L yield, as an alternative procedure to obtain 1 at a larger scale.

Exploring Cannabidiol (CBD) and Cannabigerol (CBG) Safety Profile and Skincare Potential.

Cannabinoids have long been known for their bioactive properties, with their topical application as anti-inflammatory compounds being at the forefront of research for the past decade. Concurrently, the cosmetic market is a fast-growing industry in constant need of new biomolecules. In this work, we studied the safety profile for topical applications of two cannabinoids: cannabidiol (CBD) and cannabigerol (CBG) and assessed their potential as skin care ingredients.

Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model.

Vaccine adjuvants are important for enhancing vaccine efficacy, and although aluminium salts (Alum) are the most used, their limited ability to induce specific immune responses has spurred the search for new adjuvants. However, many adjuvants fail during product development due to manufacturability, supply, stability, or safety concerns. This work hypothesizes that protein-free yeast glucans can be used as vaccine adjuvants due to their known immunostimulatory activity and high abundancy.

Considering safe and sustainable by design alternatives-Environmental hazards of an agriculture nano-enabled pesticide to non-target species.

Nanopesticides (Npes) offer improved efficacy compared to their conventional forms while reducing the usage/application rates, hence being more sustainable options. However, there is still a knowledge gap on the Npes environmental impacts. To support the safety of nano-enabled pesticides, the present study aimed at assessing the toxicity of the commercial Npe NUCOP-M and the active substance copper oxychloride, using the ecotoxicological soil model Enchytraeus crypticus and LUFA 2.