Apoptolidin A: total synthesis and partially glycosylated analogues.

The total synthesis of apoptolidin A is described employing an early glycosylation strategy. Strategic disconnections were chosen between C11-C12 (cross-coupling) and C19O-C1 (macrocyclization). The cis-selective glycosylation at C9-OH was achieved with the new SIBA protective group at O2/O3 of the L-glucose residue.

Adsorption of a diatomic molecular fluid into random porous media.

Structural and thermodynamic properties of a homonuclear hard dumbbell fluid adsorbed into a disordered hard sphere matrix are studied by means of integral equation techniques and computer simulation. In particular, we have rewritten the replica Ornstein-Zernike equations to deal with orientational degrees of freedom and we have solved them in two different approaches: the hypernetted chain equation and a semiempirical extension of Verlet's approximation. We have also derived direct expressions to calculate the chemical potential in these approximations.