Evaluation of the Immunohistochemical Scoring System of CDX2 Expression as a Prognostic Biomarker in Colon Cancer.

Encoded by the CDX2 homeobox gene, the CDX2 protein assumes the role of a pivotal transcription factor localized within the nucleus of intestinal epithelial cells, orchestrating the delicate equilibrium of intestinal physiology while intricately guiding the precise development and differentiation of epithelial tissue. Emerging research has unveiled that positive immunohistochemical expression of this protein shows that the CDX2 gene exerts a potent suppressive impact on tumor advancement in colorectal cancer, impeding the proliferation and distant dissemination of tumor cells, while the inhibition or suppression of CDX2 frequently correlates with aggressive behavior in colorectal cancer. In this study, we conducted an immunohistochemical assessment of CDX2 expression on a cohort of 43 intraoperatively obtained tumor specimens from patients diagnosed with colon cancer at Colțea Clinical Hospital in Bucharest, between April 2019 and December 2023.

Adrenal Neoplasms: Lessons from Adrenal Multidisciplinary Tumor Boards.

The radiologic diagnosis of adrenal disease can be challenging in settings of atypical presentations, mimics of benign and malignant adrenal masses, and rare adrenal anomalies. Misdiagnosis may lead to suboptimal management and adverse outcomes. Adrenal adenoma is the most common benign adrenal tumor that arises from the cortex, whereas adrenocortical carcinoma (ACC) is a rare malignant tumor of the cortex.

The Potential of Vouacapanes from Vogel Against COVID-19 Cytokine Storm.

The emergence of the COVID-19 pandemic has led to the search for potential therapeutic responses for various aspects of this disease. Fruits of Vogel (Fabaceae), sucupira, have been used in Brazilian traditional medicine because of their anti-inflammatory properties, which have been proven , and . Therefore, the aim of this work is to evaluate oleoresin and isolated diterpenes by anti-inflammatory models.

Dependence of the Surface Morphology and Micromechanical and Sclerometric Properties of AlO Layers on the Parameters of Anodizing Aluminum Alloy.

The article presents the dependence of the morphology as well as micromechanical and sclerometric properties of AlO layers on the parameters of anodizing of aluminum alloys. The oxide layers were produced on the EN AW-5251 aluminum alloy by means of a direct current anodizing in a three-component electrolyte. The input variables (current density and electrolyte temperature) were selected based on the overall design of the experiment.

Influence of Anodizing Parameters on Tribological Properties and Wettability of AlO Layers Produced on the EN AW-5251 Aluminum Alloy.

The article presents the effect of anodizing parameters of the EN AW-5251 aluminum alloy on the thickness and roughness of AlO layers as well as their wettability and tribological properties in a sliding combination with the T7W material. The input variables were the current density of 1, 2, 3 A/dm and the electrolyte temperature of 283, 293, 303 K. The tribological tests were performed on the T-17 tester in reciprocating motion, in conditions of technically dry friction.