Publications by authors named "M Teresa B Valenzuela"

Background: The Maintain Your Brain (MYB) randomised controlled trial (RCT) aimed to prevent cognitive decline and dementia through a multidomain risk-reduction intervention delivered digitally. The intervention targeted four modifiable risk areas (physical inactivity, poor diet, cognitive inactivity, and depression and/or anxiety). MYB ran for three years and targeted older Australians aged 55-77 years.

View Article and Find Full Text PDF

Background: The Maintain Your Brain (MYB) randomised controlled trial (RCT) examined the effect of a multi-domain internet-based dementia prevention program against a control group (information only) over three years among Australians aged 55-77 years. A cost-effective analysis (CEA) quantified the differences in costs (direct healthcare and program costs) and effectiveness outcomes between the intervention and control groups from a health care sector perspective.

Method: An economic evaluation was conducted alongside the MYB trial.

View Article and Find Full Text PDF

Heterozygous pathogenic variants in MBD5 (MIM*611472) and CCM2 (MIM*607929) cause autosomal dominant intellectual developmental disorder 1 (MIM#156200) and cerebral cavernous malformations-2 (MIM#603284), respectively. Both conditions may present with seizures, epilepsy, and status epilepticus. However, super-refractory status epilepticus, defined as seizures lasting more than 24 h, has not been described in either condition.

View Article and Find Full Text PDF

Unlabelled: Lung cancer is the leading cause of cancer death worldwide, also in Chile, where the main risk factor is smoking. Early detection using low-dose computed tomography has been shown to reduce mortality from this cause, but there are still no formal screening recommendations in Chile.

Aim: This initiative aimed to develop recommendations for lung cancer screening in Chile through an expert consensus process.

View Article and Find Full Text PDF

Purpose: It is possible to combine theoretical models with Monte Carlo simulations to investigate the relationship between radiation-induced initial DNA damage and cell survival. Several combinations of models have been proposed in recent years, sparking interest in comparing their predictions in view of future clinical applications.

Methods: Two in silico methods for calculating cell survival fractions were optimized for proton irradiation of the Chinese hamster V79 cell line, for LET values ranging from 3.

View Article and Find Full Text PDF