Secreted extracellular heat shock protein gp96 and inflammatory cytokines are markers of severe malaria outcome.

Malaria caused by Plasmodium spp., is a major public health issue in sub-Saharan Africa. The fight against malaria has stalled due to increasing resistance to treatments and insecticides.

Identifying populations at high risk of malaria: a mixed-methods case-control study to inform targeted interventions in Senegal.

Background: Senegal has made significant progress in reducing the burden of malaria, but transmission remains highly heterogeneous, with specific population subgroups likely at higher risk. Consultations with the National Malaria Control Programme (NMCP) and a review of available data identified nomadic pastoralists, gold miners, and Koranic school students as potential high-risk populations (HRPs). This study aimed to evaluate whether these populations are at higher risk of malaria and better characterize their exposure patterns to inform the design of targeted intervention strategies.

Advancing the prediction of bath penetration and electrochemical degradation in Hall-Héroult cell cathodes: Insights into ionic species transport in a porous electrode model.

This study presents a groundbreaking approach to modeling the Hall-Héroult cathode used in aluminum production. Our innovative model is grounded in a sophisticated porous electrode methodology coupled with state-of-the-art numerical simulations. This enables us to capture the intricate physicochemical processes within the system precisely, encompassing the migration, diffusion, and convection of ionic species.

Non-invasive point-of-care optical technique for continuous in vivo assessment of microcirculatory function: Application to a preclinical model of early sepsis.

Increased amplitude of peripheral vasomotion is a potential early marker of sepsis-related microcirculatory impairment; however, previous reports relied on clinically unsuitable invasive techniques. Hyperspectral near-infrared spectroscopy (hsNIRS) and diffuse correlation spectroscopy (DCS) are non-invasive, bedside techniques that can be paired to continuously monitor tissue hemoglobin content (HbT), oxygenation (StO), and perfusion (rBF) to detect vasomotion as low-frequency microhemodynamic oscillations. While previous studies have primarily focused on the peripheral microcirculation, cerebral injury is also a common occurrence in sepsis and hsNIRS-DCS could be used to assess cerebral microcirculatory function.

Long-Term Body Weight Trends in Gobra Zebu Cattle Reared at the 'Centre de Recherches Zootechniques' of Dahra (Senegal): A Historical Perspective (1952-2018).

The socio-economic impact of rearing Gobra zebu cattle in rural areas has yet to be demonstrated in Senegal. This impact was evident in the 1950s when a genetic breeding programme for this breed was initiated by the 'Centre de Recherches Zootechniques' of Dahra. The management of animals in this programme has evolved considerably, particularly due to the constraints encountered and the progressive acquisition of knowledge about the animals.