Publications by authors named "M Tenbusch"
Article Synopsis
- Respiratory syncytial virus (RSV) causes severe respiratory infections in young children, highlighting the need for effective vaccines.
- A new vaccine using a rare adenoviral vector (rAd19a) was compared to the more common rAd5, showing promising results in protecting against RSV when given intranasally.
- Intramuscular vaccination with rAd19a led to increased disease severity upon RSV infection, suggesting the importance of local immunity and the need for careful vaccine development to avoid enhanced disease.
Host-directed antivirals (HDAs) represent an attractive treatment option and a strategy for pandemic preparedness, especially due to their potential broad-spectrum antiviral activity and high barrier to resistance development. Particularly, dual-targeting HDAs offer a promising approach for antiviral therapy by simultaneously disrupting multiple pathways essential for viral replication. Izumerogant (IMU-935) targets two host proteins, (i) the retinoic acid receptor-related orphan receptor γ isoform 1 (RORγ1), which modulates cellular cholesterol metabolism, and (ii) the enzyme dihydroorotate dehydrogenase (DHODH), which is involved in de novo pyrimidine synthesis.
View Article and Find Full Text PDFThe pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans and swine. Swine have many physiological, anatomical, and immunological similarities to humans, and are an excellent model for human influenza. Here, we employed single cell RNA-sequencing (scRNA-seq) and flow cytometry to characterize the major leukocyte subsets in bronchoalveolar lavage (BAL), twenty-one days after H1N1pdm09 infection or respiratory immunization with an adenoviral vector vaccine expressing hemagglutinin and nucleoprotein with or without IL-1β.
View Article and Find Full Text PDFInfluenza A Virus (IAV) and Respiratory Syncytial Virus (RSV) are both responsible for millions of severe respiratory tract infections every year worldwide. Effective vaccines able to prevent transmission and severe disease, are important measures to reduce the burden for the global health system. Despite the strong systemic immune responses induced upon current parental immunizations, this vaccination strategy fails to promote a robust mucosal immune response.
View Article and Find Full Text PDFArticle Synopsis
- Early-stage breast cancer usually has a good outlook, but if it spreads, especially to the lungs, the prognosis declines; tumor-infiltrating T cells can help control tumors, particularly those with a memory function.
- A study was conducted using a vaccine to create specific T cells in the lungs of mice to prevent and treat lung metastases in breast cancer.
- The vaccine was effective in generating these T cells, reducing lung metastasis growth, and improving survival rates; when used with radiotherapy, it further enhanced outcomes for tumor-bearing mice.