Publications by authors named "M Teliti"
Article Synopsis
- Homosalate is a common UV-B filter in sunscreens that has been found to have estrogenic and anti-androgenic effects in animal models, but its impact on thyroid cells is not well understood.
- This study tested the effects of Homosalate on two types of thyroid cells (FRTL-5 and NHT) over different concentrations and time periods, finding it significantly reduced cell viability in FRTL-5 at 250μM after 72 hours and in NHT only at the highest concentration (2000μM) after 48-72 hours.
- The results showed that high concentrations of Homosalate can cause cytotoxicity, exhibit genotoxic effects in rat thyroid cells, and increase the expression of
Article Synopsis
- Fine-needle-aspiration-cytology (FNAC) is a safe and cost-effective method for assessing thyroid nodules, but indeterminate cytology (ITN) sometimes requires further diagnostic surgery.
- Recent studies from Europe and the U.S. suggest that thyroid cancer (TC) behaves differently based on pre-surgical FNAC results, with ITN cases showing less aggressive characteristics compared to more suspicious diagnoses.
- A commentary involving thyroid experts highlights the consistent finding that TC with ITN diagnosis has lower rates of complications and mutations, indicating a need to consider less aggressive treatment options for these patients.
Article Synopsis
- Radiofrequency ablation (RFA) is a safe treatment for benign thyroid nodules, but it carries a risk of injury to the recurrent laryngeal nerve (RLN), which can affect voice function.
- The study highlights the use of flexible laryngoscopy (FL) to monitor vocal cord (VC) function during RFA, ensuring safety before treating the second nodule in a patient with hyperthyroidism.
- The findings suggest that using FL is an effective way to minimize RLN injury risk during both single and bilateral RFA treatments, even when the patient is awake.
Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing.
Cytokine Growth Factor Rev
September 2024
Article Synopsis
- Population ageing is on the rise in developed countries, characterized by a decline in the functional capabilities of cells and organs, influenced heavily by inflammatory processes known as "inflamm-ageing."
- Inflamm-ageing is marked by an increase in pro-inflammatory molecules, leading to a chronic low-grade inflammatory state that can determine the overall health of elderly individuals, affecting whether they experience healthy or unhealthy ageing.
- Malnutrition is linked to worsened inflammatory responses and is a significant risk factor for sarcopenia (muscle mass loss), which contributes to frailty in the elderly, highlighting the interconnectedness of nutrition, inflammation, and the ageing process.