Publications by authors named "M Telesca"
Eur J Pharmacol
September 2024
Article Synopsis
- Heart failure (HF) is a significant global health issue, especially for the aging population; this study investigates the drug sacubitril/valsartan's effects on aging-related HF with preserved ejection fraction (HFpEF) in rats.
- After 12 weeks of treatment, both sacubitril/valsartan and valsartan showed improvements in cardiac hypertrophy, evidenced by reduced heart muscle thickness, but neither treatment effectively reduced myocardial fibrosis or corrected diastolic dysfunction.
- The study indicates that while the treatments positively impacted heart muscle size and activated cardioprotective signaling pathways, challenges like inflammation and oxidative stress remained unaddressed, leaving diastolic dysfunction and fibrosis in aging hearts.
Front Pharmacol
June 2024
Article Synopsis
- Heart failure and cognitive impairment are significant public health issues, especially as the global population ages, with strong links to age and multiple health issues.
- Type 2 diabetes increases risks for both heart and brain health, promoting conditions like heart failure and cognitive decline due to its metabolic complications.
- New anti-diabetic medications, such as GLP-1R agonists and SGLT2 inhibitors, show promise in reducing the risk of cardiovascular and neurological issues beyond just controlling blood sugar, but further research is needed to fully understand their mechanisms.
Article Synopsis
- - The study investigates whether illegal toxic waste discharge can cause a new reproductive condition called morpho-epigenetic pathozoospermia in young men who typically have normal sperm quality.
- - Findings reveal that exposure to environmental contaminants can lead to serious sperm defects and an increase in low-quality circular RNA in the seminal plasma of men living in heavily polluted areas.
- - The research involved semen samples from 160 healthy men, split between those from a contaminated region in Italy ('Land of Fires') and a control group, highlighting significant differences in sperm quality attributed to environmental pollution.
Cancers (Basel)
December 2023
Article Synopsis
- Doxorubicin (DOX), a cancer treatment, causes cardiotoxicity, with early signs showing as diastolic dysfunction and fibrosis.
- Researchers found that cardiac fibroblasts (CFs) become activated soon after DOX treatment, leading to increased metabolic activity and a shift towards glycolytic energy production.
- The changes in CFs are linked to myofibroblast differentiation and pro-fibrotic signaling, suggesting that targeting these early CF responses could help mitigate the heart damage caused by anthracycline drugs like DOX.
Article Synopsis
- Nuclear F-actin in sperm cells is vital for supporting the acroplaxome and ensuring the correct positioning of the sperm membrane protein IZUMO1, crucial for sperm-oocyte fusion.
- The study compares high-quality (A-SPZ) and low-quality (B-SPZ) human spermatozoa, revealing that excessive F-actin in B-SPZ altered the localization of IZUMO1.
- F-actin depolymerization, induced by a treatment called cytochalasin D, improved both IZUMO1 repositioning and acrosome reaction, while promoting better sperm nuclear size and histone acetylation, suggesting F-actin's significant role in sperm quality control.
