Publications by authors named "M Telatar"
Article Synopsis
- Scientists are trying to figure out how to diagnose different types of blood disorders called MDS and MPN, which can be tricky because they have some similar features.
- They looked at the DNA of patients with different types of these disorders to see how they are different and found specific gene mutations that can help identify each type.
- The research shows that age and certain mutations can affect how well patients do, and this information can help doctors make better decisions about treatment.
Article Synopsis
- * The most common mutation identified was V600E, and six out of seven acute myeloid leukemia (AML) patients had AML with monocytic differentiation, which was associated with a very poor prognosis.
- * The study suggests that while mutations are rare, they are significant in the development of certain AML subtypes and often occur with RAS pathway alterations and gene rearrangements, highlighting the need for further research to validate these conclusions.
Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is associated with a poor response to standard chemotherapy. However, outcomes with novel antibody and cellular therapies in relapsed/refractory (r/r) Ph-like ALL are largely unknown. We conducted a single-center retrospective analysis of adult patients (n = 96) with r/r B-ALL and fusions associated with Ph-like who received novel salvage therapies.
View Article and Find Full Text PDFAllogenic hematopoietic cell transplantation (alloHCT) is a well-established curative modality for acute lymphoblastic leukemia (ALL), yet large amounts of data describing alloHCT outcomes in Philadelphia (Ph)-like ALL are lacking. We retrospectively analyzed archived DNA samples from consecutive adults with B-cell Ph-negative ALL who underwent alloHCT in complete remission (CR) (n = 127) at our center between 2006 and 2020. Identification of fusions associated with Ph-like ALL was performed using cumulative results from RNA-seq, conventional cytogenetics, fluorescence in situ hybridization, and whole genome array studies.
View Article and Find Full Text PDFSimilar to poorly differentiated thyroid carcinoma (PDTC), papillary thyroid carcinoma with high-grade features (PTC HGF) demonstrates increased mitotic activity and/or necrosis; however, PTC HGF is excluded from the World Health Organization (WHO) definition of PDTC based on maintained nuclear features of PTC. Consecutive tumors that met criteria for PTC HGF, defined as tumors with maintained nuclear features of PTC and mitoses numbering 5 or more per 10 contiguous high-power fields and/or tumor necrosis, and PDTC (defined as per the WHO criteria) were identified. Clinicopathologic characteristics, follow-up data, and targeted next-generation sequencing results were compared between groups.
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