Microreactor designed for efficient plasma-liquid segmented flows.

Microreactors were designed for gas-liquid plasma chemical processes and operated under segmented flows in a high aspect ratio (8.76) rectangular microchannel. First, the hydrodynamics of the gas-liquid flows generated at a T-junction was investigated for fifteen solvents commonly used in organic synthesis.

Development of setups for real-time analysis of the effluent of a microreactor by mass spectrometry.

Monitoring a synthesis reaction in real time could allow not only the detection of the intermediates involved in the synthesis, to better understand its mechanisms, but also the impurities. Spectroscopic methods could be performed but are not so performant when analyzing complex mixtures and could require specific properties for the detection of the molecules of interest, the presence of a chromophore moiety for example. Mass spectrometry (MS) may overcome these limitations and is able to reach the accuracy and sensitivity required to efficiently detect, quantify, identify, and characterize the reagents and species produced during the synthesis.

Direct Amination of Benzene with Ammonia by Flow Plasma Chemistry.

Amine derivatives, including aniline and allylic amines, can be formed in a single-step process from benzene and an ammonia plasma in a microreactor. Different process parameters such as temperature, residence time, and plasma power were evaluated to improve the reaction yield and its selectivity toward aminated products and avoid hydrogenated or oligomerized products. In parallel, simulation studies of the process have been carried out to propose a global mechanism and gain a better understanding of the influence of the different process parameters.

Synthesis of trifluoromethyl ,-aminals from nitrogen containing heterocycles by using a plasma flow microreactor.

Trifluoromethyl ,-aminals are important precursors allowing access to fluorinated building blocks. In this work, the direct synthesis of trifluoromethyl ,-aminals from nitrogen containing heterocycles is reported using argon plasma in a continuous flow microreactor without any additives or metal catalysts. Their transformation to -trifluoroethyl amines is also reported.

Plasma flow chemistry for direct -acylation of amines by esters.

The direct -acylation of amines by esters in a microreactor is described using argon plasma, thereby producing amides in good to excellent yields.