Publications by authors named "M Tassara"
Article Synopsis
- The study investigated the roles of sex hormones, IL-10, and HLA-G in how COVID-19 affects male patients, revealing significant differences in biomarker levels compared to healthy individuals.
- Results indicated that higher IL-10 and HLA-G levels were linked to lower testosterone levels and more severe disease symptoms, with an increased risk of death for patients with low testosterone and high IL-10.
- At a 7-month follow-up, the study found that while IL-10 and testosterone levels returned to normal, HLA-G levels decreased, highlighting the biomarkers' potential in predicting COVID-19 outcomes in men.
T cell receptor (TCR)-based therapy has the potential to induce durable clinical responses in patients with cancer by targeting intracellular tumor antigens with high sensitivity and by promoting T cell survival. However, the need for TCRs specific for shared oncogenic antigens and the need for manufacturing protocols able to redirect T cell specificity while preserving T cell fitness remain limiting factors. By longitudinal monitoring of T cell functionality and dynamics in 15 healthy donors, we isolated 19 TCRs specific for Wilms' tumor antigen 1 (WT1), which is overexpressed by several tumor types.
View Article and Find Full Text PDFBackground: Circulating androgens could have a relevant pathobiological role in clinical outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19).
Objectives: We aimed to assess: (a) circulating sex steroids levels in a cohort of 286 symptomatic men with laboratory-confirmed COVID-19 at hospital admission compared to a cohort of 281 healthy men; and (b) the association between serum testosterone levels (tT), COVID-19, and clinical outcomes.
Materials And Methods: Demographic, clinical, and hormonal values were collected for all patients.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to an extensive reorganization of the healthcare system in Italy, with significant deferment of the treatment of urology patients. We aimed to assess the impact of deferred treatment during the SARS-CoV-2 pandemic on the need for blood transfusions in 3 Italian urology departments.
Methods: We reviewed hospital chart data on blood transfusions at the urology units of 3 academic centers in the north of Italy from March to April 2020.
Objective: Memory stem T (Tscm) cells are long-lived, self-renewing T cells that play a relevant role in immunologic memory. This study was undertaken to investigate whether Tscm cells accumulate in rheumatoid arthritis (RA).
Methods: The polarization and differentiation profiles of circulating T cells were assessed by flow cytometry.