Publications by authors named "M Taskiran"
Background: Several studies provide clear evidence that exposure to various infections during pregnancy are linked with an increased risk for schizophrenia. In preclinical studies, administration of polyinosinic-polycytidylic acid (Poly I:C) in pregnant rodents can induce maternal immune activation leading to impairments in brain function in the offspring.
Objectives: The aim of this study was to investigate the effect of vortioxetine, a multimodal selective serotonin reuptake inhibitor (SSRI), in the pathophysiology of Poly I:C-induced schizophrenia-like model in rats.
Introduction: Oxidative stress is known as a mechanism underlying male infertility; it is defined as an imbalance between pro-oxidants and antioxidants leading to DNA damage, peroxidation of plasma membrane lipids, and protein oxidation. This study was conducted to investigate the relationship between total antioxidant capacity and sperm parameters in male infertility.
Methods: A total of 187 men with infertility (asthenospermia group (n=51), oligospermia group (n=40), and control group (n=96) were included in the current study.
Article Synopsis
- * The study involved administering NP and TQ to different rat groups to evaluate the effects on brain health and behavior, using various tests and tissue evaluations.
- * Results indicated that NP caused significant brain damage and behavioral issues, but TQ treatment improved these conditions by reducing neuron degeneration and oxidative stress markers.
It is well established that rats exposed to inflammation during pregnancy or the perinatal period have an increased chance of developing schizophrenia-like symptoms and behaviors, and people with schizophrenia also have raised levels of inflammatory markers. Therefore, there is evidence supporting the idea that anti-inflammatory drugs may have therapeutic benefits. Aceclofenac is a nonsteroidal anti-inflammatory drug that has anti-inflammatory properties and is used clinically to treat inflammatory and painful processes such as osteoarthritis and rheumatoid arthritis, making it a potential candidate for preventive or adjunctive therapy in schizophrenia.
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- Maternal exposure to Poly I:C increases proinflammatory cytokines and induces schizophrenia-like symptoms in offspring, leading to the exploration of mGluR as a therapeutic target.
- The study aimed to assess behavioral and molecular changes in a rat model of schizophrenia, using both positive and negative allosteric modulators of mGlu1 and mGlu5 receptors.
- Results indicated that positive allosteric modulators improved behavioral outcomes and reduced proinflammatory cytokine levels, suggesting mGlu5 receptor PAMs like VU-29 could be potential treatments for schizophrenia.