Publications by authors named "M Tasaki"
Article Synopsis
- A study examined the prevalence of amyloid deposits in aortic valves from 97 patients undergoing valve replacement for aortic stenosis (AS), uncovering a significant association with junctional amyloid types.
- Results indicated that 45% of the valves contained amyloid deposits, predominantly from transthyretin-type (ATTR) and amyloid derived from ApoAI (AApoAI), which may affect clinical outcomes.
- The findings suggest that patients with amyloid deposition in the aortic valve exhibit earlier symptoms of AS despite maintaining preserved left ventricular function.
Pheochromocytoma and paraganglioma (PPGL) represent a group of rare neuroendocrine tumors known for their potential to metastasize. This study provides a comprehensive retrospective evaluation of 15 patients diagnosed with metastatic or recurrent PPGL at our institution over a two-decade span (2000-2020). Our primary objectives were to delineate the long-term clinical outcomes and pinpoint key prognostic determinants.
View Article and Find Full Text PDFBackgrounds: Evidence for C1q-fixing donor-specific antibodies (DSA) after chronic antibody-mediated rejection (CABMR) treatment is lacking. We investigated if C1q-DSA could predict therapy response in patients with biopsy-proven CABMR.
Material And Methods: Twenty kidney transplant patients with late-onset DSA were enrolled.
Article Synopsis
- ApoA-I amyloidosis is a rare systemic condition that typically affects the heart, kidneys, and liver.
- It is caused by inherited amyloidogenic variants of the APOA1 gene, passed down in an autosomal dominant way.
- The case study discusses a 69-year-old man with sporadic cardiac amyloidosis who has a homozygous variant of the APOA1 gene, stemming from his consanguineous parents.
Article Synopsis
- * Our research investigated the effects of inhibiting histone deacetylase 6 (HDAC6) in RCC cells, using 12 selective small molecule inhibitors and genetic techniques.
- * The results showed that HDAC6 inhibition reduced RCC cell viability and DNA replication, leading to increased cell death (apoptosis), suggesting potential new treatment strategies for metastatic RCC.