Publications by authors named "M Tarique"
Liver cancer, particularly Hepatocellular Carcinoma (HCC), remains a significant global health challenge owing to its high incidence and position as the fourth leading cause of cancer-related mortality. HCC represents 75-85% of all liver cancer cases and ranks as the sixth most prevalent cancer globally. Several factors, including late-stage diagnosis, limited treatment effectiveness, resistance to conventional therapies, and adverse side effects, hinder the delivery of life-prolonging care to patients with HCC.
View Article and Find Full Text PDFThis study aimed to evaluate the effects of date pomace fibers (DF) on the physicochemical properties of plant-based ground patty analogues. Previously optimized pea and wheat protein isolates were incorporated with varying concentrations of DF, i.e.
View Article and Find Full Text PDFInhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models.
Am J Physiol Gastrointest Liver Physiol
April 2025
Article Synopsis
- Chronic pancreatitis (CP) is an inflammatory disease of the pancreas without a specific cure, and this study investigates the role of the hedgehog signaling pathway in its progression.
- The researchers induced CP in mice and used the FDA-approved drug Vismodegib to inhibit the hedgehog pathway, assessing its effects on the disease's severity.
- Results showed that inhibiting hedgehog signaling improved disease parameters, halted progression, and reversed fibrosis, suggesting Vismodegib could be a promising new treatment for CP in clinical settings.
Article Synopsis
- The study examines lead (Pb) pollution in the Western Indian Ocean, using a 24-year coral record from Lakshadweep to understand historical and current contamination levels and their effects on the environment.
- Results show that lead concentrations in surface seawater nearly doubled from 1990 to 2013, mainly due to anthropogenic sources like aerosol pollution from land.
- The findings reveal significant differences in lead isotope distributions between the western and eastern Indian Ocean, indicating a substantial impact of human activity, which underscores the need for tailored environmental management in the region.
The study investigates the sources of metals in urban road dusts using elemental concentration and Pb isotopic ratios. The elemental concentrations are also utilized to determine the present heavy metal emissions as well as projected emissions till 2045. Bayesian mixing model for source apportionment highlights the significant contributions of both exhaust and non-exhaust sources to the metal-enriched urban road dusts, with each contributing approximately 40 %.
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