Suppression of 8-oxoguanine DNA glycosylase (OGG1) activity produced positive impacts on disease severity, survival, and histopathological features of mice infected with Plasmodium berghei.

Malaria is a life-threatening disease, leading to significant morbidity and mortality. Malaria treatment remains a challenge due to its intricate pathophysiology and high levels of parasite resistance to many currently available antimalarial agents. Thus, there is an urgent need for more therapeutic strategies to combat the disease.

Edgeworthia gardneri (Wall.) Meisn Mitigates CCL4-induced liver injury in mice by modulating gut microbiota, boosting antioxidant defense, and reducing inflammation.

Herbal medicine has become an area of growing global scientific interest. The prime objective of this study was to investigate the protective role of Edgeworthia gardneri (Wall.) Meisn (EGM polysaccharide) against carbon tetrachloride (CCl)-induced liver injury in mice.

Gap-free genome assemblies of two Pyrus bretschneideri cultivars and GWAS analyses identify a CCCH zinc finger protein as a key regulator of stone cell formation in pear fruit.

The Chinese white pear (Pyrus bretschneideri) is an economically significant fruit crop worldwide. Previous versions of the P. bretschneideri genome assembly contain numerous gaps and unanchored genetic regions.

Whole-genome transcriptomic profiling reveals distinct sex-specific responses to heat stroke.

Heat-related mortality remains health challenges exacerbated by climate change, with sex-based differences in outcomes, yet underlying mechanisms remain poorly understood. This study examined transcriptomic responses to heat exposure in peripheral blood mononuclear cells from 19 heat stroke patients (8 males, mean age 64.8 ± 6.

An intelligent multi-attribute decision-making system for clinical assessment of spinal cord disorder using fuzzy hypersoft rough approximations.

The data for diagnosing spinal cord disorder (SCD) are complex and often confusing, making it difficult for established diagnostic techniques to yield reliable results. This issue frequently necessitates expensive testing to get an accurate diagnosis. However, the diagnostic process can be enhanced by integrating theoretical frameworks that resemble fuzzy sets, which better manage complexity and uncertainty.