Publications by authors named "M Tarabichi"
Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic thyroid carcinoma is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an integrated thyroid cancer single-cell sequencing atlas with spatial transcriptomics and bulk RNA-sequencing, we define stromal cell subpopulations and tumor-stromal cross-talk occurring across the histologic and mutational spectrum of thyroid cancer. We identify distinct inflammatory and myofibroblastic cancer-associated fibroblast (iCAF and myCAF) populations and perivascular-like populations.
View Article and Find Full Text PDFBackground: Although glycated hemoglobin A1C (HbA1c) has classically been used for glycemic control screening before surgery, fructosamine, a short-term glucose variability indicator, has been reported to be a more accurate predictor of postoperative periprosthetic joint infection among patients with diabetes mellitus (DM). Given the variability of diabetic medication management, this study aims to identify the associated effect of glycemic control medication regimen (GCMR) on the incidence rate and associated odds of abnormal preoperative fructosamine levels among diabetic primary total knee arthroplasty or total hip arthroplasty patients.
Methods: Between 2017 and 2018, consecutive series of total hip arthroplasty and total knee arthroplasty patients were identified, and the final cohort included only diabetic patients.
Article Synopsis
- Oral potentially malignant disorders (OPMDs) with genomic changes have a higher chance of turning into oral squamous cell carcinoma (OSCC), and while tissue biopsies provide genomic data, they are invasive.
- This pilot study explores the effectiveness of non-invasive brush biopsies in profiling the genomic landscape of a patient with both OPMD and OSCC, revealing that brush biopsies accurately captured 90% of single nucleotide variants (SNVs) and matched copy number profiles with tissue biopsies.
- The results suggest that brush biopsies can identify shared genomic alterations between OPMD and OSCC lesions, showcasing their potential for understanding tumor evolution and ancestry without the need for invasive procedures.
Intra-tumor heterogeneity is an important driver of tumor evolution and therapy response. Advances in precision cancer treatment will require understanding of mutation clonality and subclonal architecture. Currently the slow computational speed of subclonal reconstruction hinders large cohort studies.
View Article and Find Full Text PDFPurpose: This paper investigates the biomechanical benefits of using hybrid constructs that combine cannulated screws with tension band wiring (TBW) cerclage compared to cannulated screws with anterior Variable Angle locking neutralisation plates (VA LNP). These enhancements can bear heavier loads and maintain the repaired patella's integrity, in contrast to traditional methods.
Method: Eighteen fresh-frozen human cadaver patellae were carefully fractured transversely at their midpoints using a saw.