Basic Science and Pathogenesis.

Background: Despite recent FDA approvement of disease-modifying treatments that reduce Aβ, the identification of novel therapeutic strategies that could delay the Alzheimer's disease (AD) development are needed. We identified and developed novel small molecule compounds that mildly inhibit mitochondrial complex I (MCI). Chronic treatment with a tool compound CP2 in 4 mouse models of familial AD was efficacious protecting against synaptic dysfunction and memory impairment, improving brain energetics and cognitive performance, reducing levels of human pTau and Ab.

Enhancing Recovery in Severe Adolescent Idiopathic Scoliosis (AIS) Patients With Cobb Angle ≥90 Degrees Undergoing Single-staged Posterior Spinal Fusion (PSF): Evaluating the Feasibility of Rapid Recovery Protocol (RRP).

Study Design: Retrospective study.

Objective: To assess the feasibility and outcome of rapid recovery protocol (RRP) in severe adolescent idiopathic scoliosis (AIS) patients with Cobb angle ≥90 degrees underwent single-staged posterior spinal fusion (PSF).

Summary Of Background Data: Corrective surgeries in severe AIS patients entail a higher risk of prolonged operation, excessive bleeding, extended hospital stay, and higher complication rates compared with non-severe AIS patients.

Students' safety culture at tertiary level academic institutes in Bangladesh: A cross-sectional study.

This study aims to investigate the safety culture of tertiary-level students in Bangladesh and identify the factors that influence it. A cross-sectional survey was conducted among 1676 students from 16 universities and medical colleges in Bangladesh to gather data. The survey consisted of a paper-based structured questionnaire with three scales: a 17-item safety beliefs and values scale, a 10-item safety perception and awareness scale, and a 14-item safety attitudes scale.

Knowledge, attitudes and practices of meat hygiene among slaughterhouse workers and retail meat sellers in Bangladesh.

Inadequate handling of raw meat leading to cross-contamination, often stemming from insufficient knowledge and practices among meat handlers, poses a significant global health challenge, especially in developing nations where food-borne diseases are prevalent. Effective understanding and implementation of preventive measures by meat handlers are essential in reducing the incidence of food-borne illnesses and the contamination of raw meat. This study aimed to assess the knowledge, attitudes, and practices regarding meat hygiene among retail meat sellers and slaughterhouse personnel in the Bogura district of Bangladesh.

Comprehensive Review of Phthalate Exposure: Health Implications, Biomarker Detection and Regulatory Standards.

Phthalates are a wide family of chemicals that are used in many different industrial applications used in many different industrial applications, including the production of plastics, toys, food packaging particularly for kids, and medical equipment. Due to their various chemical and physical properties, phthalates may negatively impact humans, animals, and the environment. Thus the potential for phthalate exposure and harm to humans, animals, and the environment is high because its presence is alarming.