Membrane progesterone receptor e (paqr9) is necessary for chorion elevation in zebrafish.

Paqr9 is a gene encoding membrane progestin receptor e (mPRe), the fifth subtype of the five mPR subtypes, and is currently classified a member of the progestin and adipoQ receptor (PAQR) family, which consists of 11 genes. To elucidate the physiological functions of the mPR subtypes, we established gene knockout (KO) fish via genome editing of seven paqr genes in zebrafish and analyzed their phenotypes. The null-mutant strain of paqr9 (paqr9) that we established in this study presented reduced chorion elevation and a high percentage of abnormal embryos.

Investigating the Impact of Chronical Prenatal Alcohol Exposure on Fetal Vascular Development Across Pregnancy Stages Using Photoacoustic Tomography.

Prenatal alcohol exposure (PAE) is a major contributor to fetal alcohol spectrum disorder (FASD), resulting in neurodevelopmental abnormalities. This study utilizes photoacoustic tomography (PAT) to investigate the effects of PAE on fetal brain vasculature in mice. PAT imaging was conducted from embryonic Day 10 (E10) to Day 20 (E20), aimed to compare two alcohol-exposed groups with a control group.

Significance of Necroptosis in Cartilage Degeneration.

Cartilage, a critical tissue for joint function, often degenerates due to osteoarthritis (OA), rheumatoid arthritis (RA), and trauma. Recent research underscores necroptosis, a regulated form of necrosis, as a key player in cartilage degradation. Unlike apoptosis, necroptosis triggers robust inflammatory responses, exacerbating tissue damage.

The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives.

Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures. The advent of bioceramics for bone regeneration has opened up auspicious pathways for addressing osteoporosis. Research indicates that bioceramics can help bones grow back by activating bone morphogenetic protein (BMP), mitogen-activated protein kinase (MAPK), and wingless/integrated (Wnt)/β-catenin pathways in the body when combined with stem cells, drugs, and other supports.