Transcriptional responses of Daphnia magna exposed to Akaki river water.

Pollution of the aquatic environment is a global problem, with industrial waste, farming effluents, sewage, and wastewater as the main contributors. Many pollutants are biologically active at low concentrations, resulting in sublethal effects, which makes it a highly complex situation and difficult to assess. In many places, such as the Akaki river in Ethiopia, the pollution situation has resulted in streams with minimal presence of invertebrates or vertebrates.

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase.

SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay.

FTIR, Raman and NMR spectroscopic and DFT theoretical studies on poly(N-vinylimidazole).

In this study where the FTIR, Raman, (1)H NMR and (13)C NMR spectra of poly(N-vinylimidazole) which can be abbreviated as poly(NVIM) are first reported, a comparison of the experimental and theoretical vibrational spectral data of monomer NVIM and water-soluble poly(NVIM) has been given; such a comparison over the vibrational modes and associated spectral data calculated at B3LYP/6-31+G(d) level of theory for NVIM and its stable dimer forms provided significant contributions for getting a reliable interpretation of the observed vibrational spectra of poly(NVIM). The obtained results revealed that the change from NVIM to poly(NVIM) should be characterized by the disappearance of the CH₂CH bonds of the vinyl group and the appearance of the aliphatic CH and CH₂ bonds. Besides this, the thermal properties of poly(NVIM) were elucidated by thermogravimetric analyses such as TGA, DTA and DSC, while some electronic structure parameters of the most stable dimers of NVIM were investigated through the structure calculations performed by using B3LYP method and 6-31+G(d) basis set within the density functional theory (DFT) methodology.

Calculation of melatonin and resveratrol effects on steatosis hepatis using soft computing methods.

In this work, beneficial effects of melatonin and resveratrol drugs on liver damage in rats, induced by application of acute and chronic carbon tetrachloride (CCl4) have been examined. The study consists of three main stages: (1) DATA ACQUISITION: light microscopic images were obtained from 60 rats separated into 10 groups after the preparation of liver tissue samples for histological examination. Rats in first five experimental groups for the four-day and the other five groups for twenty-day were examined.

[Representation and mathematical analysis of human corneal surface].

In the description and analysis of human corneal surface are used various mathematical models based on parametric representations, used in biomechanical studies and 3D solid modeling of the cornea. Mathematical models are important into the biomechanics of the cornea to model the corneal behavior. Corneal biomechanics also has the potential to improve outcomes in refractive surgery.