Lifelog Data Suggest Decreased Physical Activity Across Cancer Diagnosis and Treatment: Analysis Using Smartphone Step Count Data Linked to a Japanese Claims Database.

Background: Although physical activity is recommended for patients with cancer, changes in physical activity across cancer diagnosis and treatment have not been objectively evaluated.

Objective: To assess the impact of cancer diagnosis and treatment on physical activity levels.

Methods: This was a retrospective cohort study using a Japanese claims database provided by DeSC Healthcare Inc.

Near-infrared fluorescent HaloTag ligands for efficient organelle labelling in live cells.

A series of HaloTag ligands that incorporate near-infrared (NIR)-emissive phospha-rhodamine (POR) dyes have been developed. The PORs that contain dealkylated amino groups exhibit a hypsochromic shift in their absorption and emission wavelengths. Subsequent refinement of the POR spirocyclization equilibrium significantly enhanced membrane permeability, thereby leading to a substantial reduction in the time necessary for labelling.

A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response.

Fatty acids are known to have significant effects on the properties of cancer cells. Therefore, these compounds have been incorporated into therapeutic strategies. However, few studies have examined the effects of individual fatty acids and their interactions in depth.

Electronic patient-reported outcomes as digital therapeutics for patients with cancer: a narrative review of current practices and future directions.

Improved cancer treatment outcomes have increased the demand for medical care that considers the quality of life of patients with cancer. Patient-reported outcomes (PROs) help assess the quality of life because they involve direct evaluation of the patients. Recently, electronic PROs (ePROs) have been used in clinical cancer care settings in Europe and the United States.

ARCaDia: single-round screening of a DNA-type targeted covalent binder possessing a latent warhead.

A covalent binder for a target protein was obtained by a direct single-round screening of a latent-warhead-modified DNA library affinity/reactivity-based co-selection of aptameric deoxyribonucleic acid (ARCaDia), followed by a top -mer analysis. The optimal position of the conjugated warhead on the selected aptamer was simultaneously identified.