Publications by authors named "M Takeoka"
Article Synopsis
- A study evaluated pulmonary hemodynamics in infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) after mid-term follow-up using right heart catheterization (RHC) on 56 patients born before 28 weeks of gestation.
- Out of the 10 infants with PH defined by ultrasound, 7 were treated with sildenafil, and results showed significant improvements in PH indicators at a median age of 25 months.
- Despite improvements, half of the patients still had catheterization-defined PH, highlighting the need for continued long-term monitoring of BPD-associated PH in infants.
Article Synopsis
- The study aimed to explore if blocking the CCR2 receptor could prevent pulmonary arterial hypertension (PAH) in rat models and improve inflammatory and vascular issues.
- Researchers used genetically modified Ccr2(-/-) rats and found that these rats showed lower blood pressure in the heart, reduced inflammation, and less vascular damage after being exposed to certain treatments that typically induce PAH.
- Additionally, combining the CCR2 blockade with the PDE5 inhibitor tadalafil further improved symptoms of pulmonary hypertension, suggesting a potential therapeutic approach for PAH.
Article Synopsis
- The KRAS oncogene was previously deemed "undruggable," but the KRAS inhibitors sotorasib and MRTX1133 have shown promising results for lung cancers, while MRTX1133 is less effective for pancreatic cancer when used alone.
- Researchers discovered that these KRAS inhibitors increase certain cellular signals (STAT3 and ERK), which could lead to cancer resistance.
- Combining KRAS inhibitors with MEK and JAK2 inhibitors (like trametinib and fedratinib) could enhance treatment outcomes and tackle resistance in KRAS-mutant pancreatic cancer effectively.
Article Synopsis
- Atrial septal defect (ASD) is a common heart condition that often goes unnoticed in children, potentially leading to complications in adulthood if untreated.
- A study in Japan analyzed data from children with ASD who underwent procedures for closure, revealing that 37% were identified through school ECG screenings, especially those older than 6 years.
- The results indicate that ECG screenings are effective in detecting significant ASDs in asymptomatic students, highlighting their importance in early diagnosis and management.
Background: Bronchopulmonary dysplasia (BPD) persists as one of the foremost factors contributing to mortality and morbidity in extremely preterm infants. The effectiveness of administering sildenafil early on to prevent BPD remains uncertain. The aim of this study was to investigate the efficacy and safety of prophylactically administered sildenafil during the early life stages of preterm infants to prevent mortality and BPD.
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