[Possible influence of genetic polymorphism in the area of GSTs genes on the serum PCB level].

Objective: To find out whether the serum PCB level depends on genetic polymorphism in the area of GSTs genes.

Material And Methods: In the group of 147 men (112 with an average age of 59.1 ± 10.

Thyroid volume, iodine intake, autoimmune thyroid disorders, inborn factors, and endocrine disruptors: twenty-year studies of multiple effects puzzle in Slovakia.

Objective: The aim of this study was to evaluate multiple interrelations between several endogenous and exogenous effects and the thyroid volume and function in large groups of children, adolescents, and adults with a sufficient whole life intake of the iodine.

Subjects And Methods: The data were obtained either by cross sectioned or longitudinal studies in a total of 4998 children and adolescents (aged 7 to 17 years) and 2501 adults (1071 males and 1430 females aged 20-75 years). Thyroid volume (ThV) was measured by ultrasound, antibodies, and hormones by electrochemiluminiscent immunoassay, and endocrine disruptors (EDs, polychlorinated biphenyls-PCB, dichlorodiethyl-ichloroethylene-DDE, and hexachlorobenzene-HCB) by high resolution gas chromatography/mass spectrometry.

[Medicines and thyroid gland].

From their primary pharmacological effect, many drugs may also affect the thyroid gland function or the results of thyroid function tests. In addition to the drugs with a known effect on thyroid gland, including thionamides, thyroid hormones, recombinant TSH, iodine, iodide, amiodarone, lithium and heparin, novel compounds, including tyrosin-kinase inhibitors, immunomodulators and cytokines also have adverse effects on the thyroid gland. Novel drugs are then associated with new types of adverse thyroid effects.

Microsomal epoxide hydrolase polymorphisms, cigarette smoking and prostate cancer risk in the Slovak population.

Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of this enzyme is affected by two polymorphisms, a substitution of Tyr113 by His in exon 3 and a substitution of His139 by Arg in exon 4.

Serum levels of leptin, adiponectin, retinol binding protein 4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese.

Aim: To determine the relationship between some adipokines and insulin resistance (IR) in obese.

Materials And Methods: 47 individuals were divided--1. according to BMI to subgroups with normal weight, overweight and obesity, 2.