Publications by authors named "M Tainta"
Article Synopsis
- Blood-derived DNA methylation shows potential for early detection of dementia risk, linking biological factors with lifestyle and environmental influences.
- A multivariate methylation risk score (MMRS) was developed, predicting mild cognitive impairment independently of age and sex, alongside significant future risk of cognitive decline in Alzheimer’s and Parkinson’s diseases.
- The study highlights the integration of machine learning and omics data to enhance dementia risk prediction at the population level.
Article Synopsis
- The study examined DNA methylation patterns in blood samples related to 15 key biomarkers of Alzheimer's disease, focusing on neuroinflammation and neurodegeneration effects.
- Using 885 samples from the EMIF-AD study, researchers identified significant differential methylation connected to CSF levels of YKL-40 and neurofilament light chain (NfL).
- Findings suggest a link between YKL-40 DNA methylation and genetic variants, with implications for understanding how DNA methylation influences protein levels relevant to Alzheimer's disease.
Introduction: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations.
Methods: We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from EMIF-AD MBD and ADNI. For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models.
Background: Structural and functional changes of the choroid plexus (ChP) have been reported in Alzheimer's disease (AD). Nonetheless, the role of the ChP in the pathogenesis of AD remains largely unknown. We aim to unravel the relation between ChP functioning and core AD pathogenesis using a unique proteomic approach in mice and humans.
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- The study investigated the role of neurodegeneration markers (neurogranin, neurofilament light, and hippocampal volume) in Alzheimer's disease using cerebrospinal fluid proteomics.
- A small number of individuals exhibited both amyloid and tau pathology with either neurogranin or neurofilament light, showing distinct proteomic profiles based on these markers.
- The findings suggest that neurogranin might not be the best indicator of neurodegeneration and that different markers provide unique insights into the disease, helping refine staging beyond just amyloid and tau levels.