Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties.

The role of the mechanical environment in defining tissue function, development and growth has been shown to be fundamental. Assessment of the changes in stiffness of tissue matrices at multiple scales has relied mostly on invasive and often specialist equipment such as AFM or mechanical testing devices poorly suited to the cell culture workflow.In this paper, we have developed a unbiased passive optical coherence elastography method, exploiting ambient vibrations in the sample that enables real-time noninvasive quantitative profiling of cells and tissues.

Axisymmetric ridges and circumferential buckling of indented shells of revolution.

When poking a thin shell-like structure, like a plastic water bottle, experience shows that an initial axisymmetric dimple forms around the indentation point. The ridge of this dimple, with increasing indentation, eventually buckles into a polygonal shape. The polygon order generally continues to increase with further indentation.

Effect of the anisotropic permeability in the frequency dependent properties of the superficial layer of articular cartilage.

Articular cartilage is a tissue of fundamental importance for the mechanics of joints, since it provides a smooth and lubricated surface for the proper transfer of loads. From a mechanical point of view, this tissue is an anisotropic poroviscoelastic material: its characteristics at the macroscopic level depend on the complex microscopic architecture. With the ability to probe the local microscopic features, dynamic nanoindentation test is a powerful tool to investigate cartilage mechanics.

Static bistability of spherical caps.

Depending on its geometry, a spherical shell may exist in one of two stable states without the application of any external force: there are two 'self-equilibrated' states, one natural and the other inside out (or 'everted'). Though this is familiar from everyday life-an umbrella is remarkably stable, yet a contact lens can be easily turned inside out-the precise shell geometries for which bistability is possible are not known. Here, we use experiments and finite-element simulations to determine the threshold between bistability and monostability for shells of different solid angle.