Publications by authors named "M Tachdjian"
Comparison of clinical selection-based genetic testing with phenotype-agnostic extensive germline sequencing to diagnose genetic predisposition in children with cancer: a prospective diagnostic study.
Lancet Child Adolesc Health
October 2024
Article Synopsis
- The study examines the effectiveness of two methods for identifying cancer predisposition syndromes (CPS) in children with newly diagnosed cancers in a Dutch pediatric oncology center.
- Out of 1052 eligible children, 733 underwent both a phenotype-driven approach and a broader phenotype-agnostic gene sequencing, identifying 53 cases of CPS.
- The phenotype-agnostic method revealed more CPS cases, demonstrating that broad genetic sequencing can be more effective than clinical selection based solely on symptoms.
Background: Li-Fraumeni syndrome (LFS) is a penetrant cancer predisposition syndrome (CPS) associated with the development of many tumor types in young people including osteosarcoma and breast cancer (BC). The McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) decision-support tool provides a standardized approach to identify patients at risk of CPSs.
Methods: We conducted a cost-utility analysis, from the healthcare payer perspective, to compare MIPOGG-guided, physician-guided, and universal genetic testing strategies to detect LFS in female patients diagnosed at an age of less than 18 years with osteosarcoma.
Article Synopsis
- Prompt diagnosis of cancer predisposition syndromes (CPS) in children is crucial for effective management and genetic counseling, but many institutions lack the necessary resources for accurate diagnoses.
- The McGill Interactive Pediatric OncoGenetic Guidelines (MIPOGG) tool was evaluated for its accuracy in predicting CPS in pediatric oncology patients, involving 1,071 participants across multiple centers.
- Results showed that MIPOGG successfully identified 99.5% of patients with confirmed CPS, outperforming standard clinical practices in early detection.
Long-term follow-up of the flexor carpi ulnaris transfer in spastic hemiplegic children.
J Pediatr Orthop
August 1988
A retrospective study was performed on 25 patients with cerebral palsy who underwent transfer of the flexor carpi ulnaris to the radial wrist extendors. The mean age at the time of surgery was 8 years 1 month. The mean follow-up was 8 years 7 months.
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