L-2-hydroxyglutaric aciduria: identification of ten novel mutations in the L2HGDH gene.

L-2-hydroxyglutaric aciduria (L-2-HGA) is a metabolic disease with an autosomal recessive mode of inheritance. It was first reported in 1980. Patients with this disease have mutations in both alleles of the L2HDGH gene.

What happens to long-term medication when general practice patients are referred to hospital?

Objective: The aim of the study was to determine changes in drug treatment of general practitioners' patients on hospital admission and after discharge, and to identify communication problems.

Methods: During 15 months all chronically ill patients of one general practice who were referred to hospital (n = 130) were followed-up prospectively with regard to long-term medication in general practice, drugs recommended in hospital for continuing treatment and medication after discharge from hospital.

Results: Before hospital admission the 130 patients were receiving 420 medicines long-term (14% generic drugs).