Publications by authors named "M T de la Morena"
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the immunopathology associated with each phenotype. Although defective T and B cell development is common to all phenotypes, patients with hypomorphic variants can generate T and B cells with signatures of immune dysregulation and produce autoantibodies to a broad range of self-antigens, including type I interferons.
View Article and Find Full Text PDFPost-Traumatic Stress Disorder (PTSD) is a complex psychiatric condition arising from traumatic experiences, marked by abnormal fear memories. Despite women are twice as likely as men to develop PTSD, the biological mechanisms underlying this disparity remain inadequately explored, particularly in preclinical studies involving female subjects. Previous research shows that female rats exhibit active fear responses, while males display passive behaviors.
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- Pathogenic variants in a specific transcription factor are linked to syndromes like EEC and AEC, and this case report presents an infant with severe T cell lymphopenia, detected during newborn screening.
- Flow cytometry revealed low levels of CD4+ and almost no CD8+ T cells, while the B and NK cell levels were normal; further genetic analysis identified a particular variant in the transcription factor.
- Using an artificial thymic organoid system, researchers found that T cell differentiation occurred, implying a thymic defect, leading to the patient receiving an allogenic cultured thymus tissue implant, which showed promising signs of T cell development after 9 months.
Article Synopsis
- The study investigates the presence and prevalence of canine vector-borne diseases (CVBD) on Boa Vista Island in Cape Verde, focusing on pathogens like Ehrlichia canis, Leishmania infantum, and others in 150 dogs, including strays and pets.
- A high seroprevalence of Ehrlichia canis was found at 82%, with many infected dogs showing no clinical symptoms despite high antibody levels.
- Co-infections were common, with some dogs testing positive for multiple pathogens, highlighting the complex epidemiology of CVBD in tropical regions.
Article Synopsis
- * Research indicates that activation patterns in the BLA differ based on the type of stimulus, with aversive stimuli causing stronger activation in specific medial areas of the BLA and stressful stimuli leading to longer activation durations.
- * The study highlights the need for further research into the molecular and circuit-level specifics of the BLA's activation during stress, with norepinephrine playing a key role in enhancing neuron responses in these situations.