BMSCs-derived small extracellular vesicles antagonize cerebral endothelial Caveolin-1 driven autophagic degradation of tight-junction proteins to protect blood-brain barrier post-stroke.

Bone marrow mesenchymal stem cells (BMSCs) -derived extracellular vesicles (EVs), especially small EVs (sEVs), were vastly reported to enable multiple restorative effects on ischemic stroke, yet the protective mechanism of blood-brain barrier (BBB) has not been fully illustrated. In the present study, we investigated the therapeutic effects and mechanism of BMSCs-derived sEVs on BBB injury after ischemic stroke. In-vivo, administering sEVs to transient middle cerebral artery occlusion (tMCAo) mice mitigated the brain infarct volume, BBB permeability and neural apoptosis, and improved the cerebral blood flow perfusion and neurological function.

Erratum: Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum.

[This corrects the article DOI: 10.7150/ijbs.46153.

Erratum: MRPS16 facilitates tumor progression via the PI3K/AKT/Snail signaling axis: Erratum.

[This corrects the article DOI: 10.7150/jca.39671.

[Protective effect of tumor necrosis factor receptor-associated factor 6 inhibitor C25-140 on acute kidney injury induced by diquat poisoning in mice].

Objective: To investigate the protective effect and mechanism of tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibitor C25-140 on acute kidney injury (AKI) induced by acute diquat (DQ) poisoning in mice.

Methods: A total of 80 SPF grade healthy male C57BL/6 mice were randomly divided into the normal control group, DQ model group, C25-140 intervention group, and C25-140 control group, with 20 mice in each group. The DQ poisoning mouse model was established by using one-time intraperitoneal injection of 1 mL of 40 mg/kg DQ solution.

China's product-level CO emissions dataset aligned with national input-output tables from 1997 to 2020.

Carbon emission research based on input-output tables (IOTs) has received attention, but data quality issues persist due to inconsistencies between the sectoral scopes of energy statistics and IOTs. Specifically, China's official energy data are reported at the industry level, whereas IOTs are organized by product sectors. Valid IOT-based environmental models require consistent transformation from industry-level to product-level emissions.