Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate.

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million people are infected by this parasite of which 20-30% will progress to develop Chronic Chagasic Cardiomyopathy (CCC). Despite its high disease burden, no clinically approved vaccine exists for the prevention or treatment of CCC.

Internalizing Pathways to Adolescent Substance Use from Adverse Childhood Experiences.

The mediating role of anxious, depressive, and somatic symptoms was examined in the association between adverse childhood experiences (ACEs) and adolescent substance use, with attention to the unique effects of each set of symptoms within the same model. Adolescents (n = 701) were assessed over time (ages 3-17) in a majority male (70.5%) and white (89.

Hydration profile of the Latin American population and the contribution of total daily pure water. The ELANS study.

Introduction: water is a crucial component of human health useful for various bodily functions. Despite its importance, previous research has largely overlooked hydration in Latin America, focusing instead on regions with greater access to a variety of food sources. Objective: hence, this study provides comprehensive data on water consumption patterns in this region and analyses the hydration profiles of urban Latin American populations, emphasizing the role of pure water in daily intake.