A novel pathogenic frameshift variant in AXIN2 in a man with polyposis and hypodontia.

Background: WNT signaling is pivotal in embryogenesis and tissue homeostasis. Aberrant WNT signaling, due to mutations in components of this pathway, contributes to the development and progression of human cancers, including colorectal cancer. AXIN2, encoded by the AXIN2 gene, is a key negative regulator and target of the canonical WNT signaling pathway.

Factors associated with anxiety and depressive symptoms in colorectal cancer survivors.

Background: Up to 37% of colorectal cancer (CRC) survivors report depressive and anxiety symptoms. The identification of risk factors for depressive or anxiety symptoms might help focus supportive care resources on those patients most in need. The present study aims to explore which factors are associated with heightened anxiety or depression symptom severity.

Ambulatory monitoring of physical activity in working situations, a validation study.

How to assess a patient's functional physical mobility in non-laboratory situations has been a problem for the medical services for a long time. A measurement system using accelerometry (DynaPort ADL Monitor) has been developed to cope with this problem. It is a lightweight recorder that is worn around the waist.