Publications by authors named "M T Tagle"

We report the case of a patient with chronic hepatitis B and C managed with direct-acting antivirals in an outpatient setting. Chronic hepatitis B was first treated with entecavir before initiating treatment for chronic hepatitis C. The patient achieved viral suppression for hepatitis B and sustained virological response for hepatitis C.

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Article Synopsis
  • A comprehensive study analyzed 468 cases of idiosyncratic drug-induced liver injury (DILI) in Latin America over a decade, revealing key demographic details such as a predominance of women (62%) and a mean age of 49 years.
  • The analysis found that hepatocellular injury was the most common (62%), with significant occurrences of jaundice (60%) and hospitalization (42%), while 4.1% of cases resulted in fatal outcomes.
  • The study highlights a rising incidence of liver injuries linked to herbal and dietary supplements, as well as specific drugs like nimesulide and nitrofurantoin, suggesting the need for public health initiatives to educate on the risks associated with these medications.
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Background & Aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), which despite being increasingly reported, remains largely undefined. We aimed to describe in-depth the features of this entity in a large series of patients from two prospective DILI registries.

Methods: DILI cases with autoimmune features collected in the Spanish DILI Registry and the Latin American DILI Network were compared with DILI patients without autoimmune features and with an independent cohort of patients with AIH.

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Background: Nonsteroidal anti-inflammatory exacerbated respiratory disease (N-ERD) is characterized by the Samter triad: chronic rhinosinusitis with nasal polyps, asthma, and nonallergic hypersensitivity to NSAIDs. Its diagnosis is based on a complete clinical history and an aspirin (ASA) challenge test. Medical treatments include biological drugs and ASA desensitization.

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Typhlitis, is also known as neutropenic enterocolitis, affects the cecum and distal ileum. It was frequently encountered in pediatric patients who were undergoing treatment for leukemia. Nonetheless, it can affect adult patients, regardless of the cause of the immunosuppression.

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