Plastic nanoparticle toxicity is accentuated in the immune-competent inflamed intestinal tri-culture cell model.

Important cell-based models of intestinal inflammation have been advanced in hopes of predicting the impact of nanoparticles on disease. We sought to determine whether a high level and extended exposure of nanoplastic might result in the added intestinal inflammation caused by nanoplastic reported in a mouse model of irritable bowel disease. The cell models consist of a Transwell©-type insert with a filter membrane upon which lies a biculture monolayer of Caco-2 and HT29-MTX-E12 made up the barrier cells (apical compartment).

Motor imagery does not effectively improve walking-related performance in older adults: A randomised controlled trial.

Background: Inaccurate perception of one's physical abilities is potentially related to age-related declines in motor planning and can lead to changes in walking. Motor imagery training is effective at improving balance and walking in older adults, but most research has been conducted on older adults following surgery or in those with a history of falls. Deficits in motor imagery ability are associated with reduced executive function in older adults with cognitive impairment.

Predictions of adolescents' responses to the Youth Self-Report from parental attachment interviews collected during pregnancy: a 17-year longitudinal study.

This study investigated the influence of parents' Adult Attachment Interview (AAI) responses prior to the birth of a first child, on self-reported mental health symptoms of the first-born child in mid-adolescence. The sample comprised 51 first-born children aged 16 years, their mothers and fathers from a low-risk community urban sample, White, British and 70% middle class. Mothers' responses to the AAI were the strongest predictor of their adolescent children's self-reported mental health symptoms.

Donor derived cell free DNA in lung transplant recipients rises in setting of allograft instability.

Purpose: The purpose of this study was to evaluate the correlation between longitudinal monitoring of donor-derived cell free DNA (dd-cfDNA) in lung transplant recipients and a "gold standard" of existing tools (pulmonary function testing, radiographic imaging, laboratory and bronchoscopy data, clinical judgment) to assess allograft function.

Methods: 24 consecutive transplant recipients were prospectively enrolled in this study measuring dd-cfDNA levels monthly in the first year after bilateral lung transplant. Blinded clinical adjudications were performed at the same timepoints to categorize allograft function as stable (FEV1 within 10% of prior value or when compared to best two averaged post-transplant values) or unstable.

Effects of lactose content in milk replacer on apparent digestibility, growth, liver messenger RNA expression, and blood parameters related to metabolism of dairy calves.

Even with the same energy supply, differences in energy sources may affect calf growth and metabolism. In this study, we evaluated the effects of feeding 3 different milk replacers (MR) with different lactose supplies under isoenergetic conditions on calf digestibility, growth, and metabolism-related markers. Fifteen Holstein bull calves were randomly assigned to one of 3 MR feeding treatments: low lactose (L: 38%), medium lactose (M: 41%), or high lactose (H: 46%).