Toddler's fracture: an updated guide on evaluation and management.

Toddler's fractures are commonly encountered in pediatric healthcare. These injuries are associated with little to no risk of fracture displacement or failure to heal, regardless of treatment modality. The standard treatment for these injuries has historically been several weeks of weightbearing restriction and immobilization in a circumferential cast or posterior splint.

The Role of Protein-Lipid Interactions in Priming the Bacterial Translocon.

Protein-lipid interactions demonstrate important regulatory roles in the function of membrane proteins. Nevertheless, due to the semi-liquid nature and heterogeneity of biological membranes, and dissecting the details of such interactions at high resolutions continues to pose a major challenge to experimental biophysical techniques. Computational techniques such as molecular dynamics (MD) offer an alternative approach with both temporally and spatially high resolutions.

Quality of care in hepatocellular carcinoma-A critical review.

There is significant variation in HCC management across different centers with poor adherence to evidence-based clinical practice guidelines as assessed in prior studies. In Australia, quality indicators (QIs) have recently been proposed by a multidisciplinary group of experts to help provide a framework to assess and monitor the quality of HCC care. In this review, we discuss the many areas where real-world practice deviates from evidence-based medicine, the role that QI sets play in addressing this gap, and the similarities and differences between Australian QIs and other leading treatment guidelines and QI sets from around the world.

Dose-dependent effects of alcohol consumption on pressure pain threshold.

Introduction: Prior laboratory-based studies have identified significant analgesic effects of acute alcohol. Despite providing excellent experimental control, these studies are limited regarding the range of alcohol exposure that can be practically and ethically achieved. This study capitalized on the heterogeneity in breath alcohol concentration (BrAC) resulting from naturalistic alcohol use at a public event to improve understanding of alcohol analgesia.

Management of Muscle Cramps in Patients With Cirrhosis: A Systematic Review of Randomised Controlled Trials.

Background: Muscle cramps are common in patients with cirrhosis. Despite their prevalence and impact on health-related quality of life, there are no widely used clinical practice guidelines for management of muscle cramps in cirrhosis. The aim of this review was to critically evaluate current evidence regarding treatment of muscle cramps in cirrhosis.