HPV Vaccine Uptake and its Predictors among Adolescent Girls and Young Women Living with HIV-in Central Uganda.

This study aimed to assess HPV vaccine uptake and its predictors among adolescent girls and young women living with HIV. We analyzed cross-sectional baseline data from a pilot randomized controlled trial involving 100 girls and young women (aged 10-24 years) living with HIV and receiving care in Uganda's Greater Masaka region. The study was conducted in four Antiretroviral(ART) providing healthcare facilities between January and March 2024.

Identification and Treatment of Intravascular Hypervolemia and Polycythemia in Patients With Heart Failure: Role of Therapeutic Phlebotomy.

Intravascular hypervolemia with polycythemia is a blood volume phenotype in patients with heart failure that portends additional risks including thrombotic events. This paper presents 4 patients with heart failure with this blood volume phenotype and focuses on its identification and the role of therapeutic phlebotomy including patient selection and outcomes.

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T-tubule pH regulation.

Disruption of extracellular pH and proton-sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH-sensitive fluorescent protein pHluorin2, tethered to the extracellular face of the plasma membrane using a glycosylphosphatidylinositol (GPI) anchor. Monitoring of pHluorin2 with ratiometric fluorescence revealed dynamic and discrete domains of extracellular acidification over the first 72 h of embryonic development.

Delivering Guideline-Concordant Care for Patients With High-Risk HPV and Normal Cytologic Findings.

Importance: As US health care systems shift to human papillomavirus (HPV)-based cervical cancer screening, more patients are receiving positive high-risk non-16/18 genotype HPV results and negative for intraepithelial lesion or malignancy (NILM) cytological findings. Risk-based management guidelines recommend 2 consecutive negative annual results to return to routine screening.

Objective: To quantify patterns of surveillance testing and associated outcomes for patients after an HPV-positive results and NILM cytologic findings.

Support groups for family members of older adults in residential aged care: A pilot feasibility study.

Objectives: There are limited mental health support services in Australia that address the well-being of family members of aged care residents. The aim of this project was to evaluate the feasibility, acceptability and preliminary effectiveness of an online program designed to support residents' families.

Methods: This one-arm mixed methods project examined uptake, attendance and retention patterns, satisfaction and experience with the service, and pre- and postoutcomes with respect to depressive and anxiety symptoms and loneliness.