Publications by authors named "M T Shore"

Acting for the greater good often involves paying a personal cost to benefit the collective. In two studies, we investigate how children (N = 184, M = 8.02 years, SD = 1.

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In developmental psychology, the widespread adoption of new methods for testing children does not typically occur over a matter of months. Yet, the COVID-19 pandemic and its associated social distancing requirements created a sudden need among many research groups to use a new method with which they had little or no experience: online testing. Here, we report results from a survey of 159 researchers detailing their early experiences with online testing.

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The microbial community associated with animals (microbiome) is essential for development, physiology, and health of host organisms. A critical step to understand the assembly of microbiomes is to determine how effectively bacteria colonize and establish within the host. Bacteria commonly colonize hosts through vertical transmission, passively from the environment, or through food consumption.

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T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-seq) to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma. We identify potential effectors of anti-tumor immunity in subsets of T cells that co-express cytotoxic programs and several natural killer (NK) cell genes.

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Article Synopsis
  • Synovial sarcoma (SyS) is an aggressive cancer driven by the SS18-SSX fusion, showing low levels of T cell infiltration, which indicates immune evasion.
  • Researchers used single-cell RNA sequencing to analyze 16,872 cells from human SyS tumors, identifying a key malignant subpopulation linked to poorer clinical outcomes and immune-deprived areas.
  • The study found that the malignant cell state is influenced by the SS18-SSX fusion and can be targeted with a combination of HDAC and CDK4/CDK6 inhibitors, boosting T cell responses and enhancing treatment effectiveness.
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