Publications by authors named "M T Sargsyan"
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common form of autoimmune encephalitis, presenting with various psychiatric manifestations, including behavioral and cognitive impairments, movement disorders, decreased consciousness, dysphasia, seizures, and autonomic dysfunction. Autonomic dysfunction may involve hyperthermia, apnea, hypotension, tachycardia, and life-threatening manifestations of sinus node dysfunction (SND), such as bradycardia, sinus pause or arrest, and asystole. The severity and significance of SND are critical, as it is not uncommon for these patients to progress into asystolic cardiac arrest, potentially contributing to morbidity and mortality.
View Article and Find Full Text PDFCardiomyopathy is defined as structural and functional myocardial abnormality not attributed to ischemic, valvular, hypertensive, or congenital cardiac causes. The main phenotypes of cardiomyopathy include hypertrophic, dilated, non-dilated left ventricular, restrictive, arrhythmogenic right ventricular, Takotsubo, and left ventricular noncompaction cardiomyopathies. A significant proportion of dilated cardiomyopathy (DCM) cases represents patients with genetic mutations, most commonly titin gene truncating variants (TTNtv).
View Article and Find Full Text PDFArticle Synopsis
- Takayasu arteritis (TA) is a rare condition that causes inflammation of the aorta and its major branches, leading to issues like thickening and narrowing of the arteries, which can result in blood clots and organ ischemia.
- A case involving a 16-year-old girl showed TA affecting her left main coronary artery, resulting in severe narrowing that required a stent placement to treat.
- Unfortunately, seven months after the procedure, she experienced cardiac arrest due to complete blockage of the stent, highlighting the potential severe complications associated with this disease.
Article Synopsis
- The study investigates the antiviral effects of newly synthesized heterocyclic compounds against SARS-CoV-2, aiming to explore their potential as treatment options due to the severity of COVID-19.
- The research utilized various methods including cell culturing and qRT-PCR to analyze the compounds' effectiveness, showing that they significantly reduced the viral load and improved symptoms in infected hamsters.
- Results indicated that these compounds not only decreased SARS-CoV-2 replication in vitro but also positively affected pathological changes in hamsters, suggesting their potential for further development as antiviral drugs.
Left ventricular thrombus (LVT) has historically been reported as a complication of acute left ventricular (LV) myocardial infarction. It is most commonly observed in cases of LV systolic dysfunction attributed to ischemic or nonischemic etiologies. Conversely, the occurrence of LVT in normal LV systolic function is an exceptionally rare presentation and is predominantly associated with conditions such as hypereosinophilic syndrome (HES), cardiac amyloidosis, left ventricular noncompaction, hypertrophic cardiomyopathy (HCM), hypercoagulability states, immune-mediated disorders, and malignancies.
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