Aspartate signalling drives lung metastasis via alternative translation.

Lung metastases occur in up to 54% of patients with metastatic tumours. Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment that may favour the survival of cancer cells. Moreover, secreted factors from primary tumours alter immune cells and the extracellular matrix of the lung, creating a permissive pre-metastatic environment primed for the arriving cancer cells.

Description of tissue profiles, thalamic location, and recommended penetrating captive bolt placement in cadaver heads from domesticated 24- to 48-mo-old male yaks ().

Yaks are a domesticated species utilized for meat, fiber, and transportation in many countries. In the United States, yak meat is growing in popularity due to its classification as a "healthy" meat. Penetrating captive bolt (PCB) is an approved method of preslaughter stunning and euthanasia for cattle.

Troubling Trends in Biomedical Research Publication: "Publish or Perish" Results in a Propensity for Ethical Violations.

As a result of the "publish or perish" environment for biomedical journal authors, as well as new developments in open access publication models ("pay to publish") and rapid improvements in artificial intelligence large language models (like ChatGPT), troubling trends and a propensity for ethical violations now exists. Credit is commonly being taken for authorship by those who fail to meet authorial criteria, which is unethical. Experienced co-authors are providing inadequate diligence in drafting, critical review, and final approval of submitted articles, which is unethical, or at the very least, careless.

Alpha-synuclein RT-QuIC assay in gastroduodenal and skin biopsies of Parkinson disease patients.

In this study, we compared the value of pathological alpha-synuclein (αSyn) seed amplification assay (SAA) in gastric and duodenal biopsies with skin biopsies in Parkinson disease (PD) patients with different disease duration. The accuracy of αSyn SAA was 87.7% in skin, 67.