We determine the complete atomic-level structure of the amorphous form of the drug atuliflapon, a 5-lipooxygenase activating protein (FLAP) inhibitor, chemical-shift-driven NMR crystallography. The ensemble of preferred structures allows us to identify a number of specific conformations and interactions that stabilize the amorphous structure. These include preferred hydrogen-bonding motifs with water and with other drug molecules, as well as conformations of the cyclohexane and pyrazole rings that stabilize structure by indirectly allowing for optimization of hydrogen bonding.
View Article and Find Full Text PDFWe assess the strategic alignment of attitudes and the active construction of attitude-based identity across two studies. Study one assessed the twitter response (hashtags in English) to the war in Ukraine for five months after Russia's first invasion of Ukraine 2022 (N = 8149). Results demonstrated that individuals publicly expressed hashtags similar to others close to them in the followership network, showing their support for Ukraine and condemnation of the Russian invasion in qualitatively different ways.
View Article and Find Full Text PDFSocial bots, employed to manipulate public opinion, pose a novel threat to digital societies. Existing bot research has emphasized technological aspects while neglecting psychological factors shaping human-bot interactions. This research addresses this gap within the context of the US-American electorate.
View Article and Find Full Text PDFTo describe advances in 3D data capture and printing that allow photorealistic replicas of human anatomical specimens for education and research, and discuss advantages of current generation printing for replica design and manufacture. We combine surface scanning and computerized tomography datasets that maximize precise color and geometric capture with ultra violet (UV) curable resin printing to replicate human anatomical specimens. We describe the process for color control, print design and translation of photorealistic 3D meshes into 3D prints in durable resins.
View Article and Find Full Text PDFResearch has found that psychological groups based on opinion congruence are an important group type. Previous research constructed such groups around opinions potentially connected to pre-existing identities. We strip away the socio-structural context by using novel opinions to determine whether opinion congruence alone can be a category cue which can foster identification and whether such group identification mediates the relationship between opinion exposure and opinion polarization.
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