Publications by authors named "M T Quaranta"
Patients with familial adenomatous polyposis (FAP) harbor mutations in the APC gene and will develop adenoma and early colorectal cancer. There is no validated treatment, and animal models are not sufficient to study FAP. Our aim was to investigate the early events associated with FAP using the intestinal organoid model in a single-center study using biopsies from nonadenomatous and adenomatous colonic mucosa of FAP patients and from healthy controls (HCs).
View Article and Find Full Text PDFFamilies and Businesses in Delaware Share a Common Challenge: Child Care.
Dela J Public Health
October 2024
Background: Cytoreductive surgery is critical for optimal tumor clearance in advanced epithelial ovarian cancer (EOC). Despite best efforts, some patients may experience R2 (>1 cm) resection, while others may not undergo surgery at all. We aimed to compare outcomes between advanced EOC patients undergoing R2 resection and those who had no surgery.
View Article and Find Full Text PDFThe SARS-CoV-2 pandemic, responsible for approximately 7 million deaths worldwide, highlights the urgent need to understand the molecular mechanisms of the virus in order to prevent future outbreaks. The Spike glycoprotein of SARS-CoV-2, which is critical for viral entry through its interaction with ACE2 and other host cell receptors, has been a focus of this study. The present research goes beyond receptor recognition to explore Spike's influence on cellular metabolism.
View Article and Find Full Text PDFArticle Synopsis
- - The World Health Organization reported that in 2022, 10.6 million people were diagnosed with tuberculosis (TB) and 1.3 million died, highlighting a growing problem with multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains of the bacteria.
- - TB bacteria have adapted to survive inside host cells by producing their own amino acids, which means targeting amino acid biosynthesis could help develop new treatments that outsmart the bacteria's defenses.
- - Recent progress in drug discovery shows that inhibitors of tryptophan biosynthesis are promising, suggesting that focusing on optimizing these compounds could enhance the development of effective TB therapies in the future.