Publications by authors named "M T Pueyo"
Article Synopsis
- The systematic review investigates how carbohydrate (CHO) intake affects soccer players' physical performance, cognitive function, and muscle glycogen levels, as well as possible differences between male and female players.
- A search of scientific literature found 61 relevant articles, adhering to established review guidelines, which led to the discovery that CHO consumption enhances speed, sprinting ability, and mental performance, while there is no clear impact on skills like dribbling and passing.
- It is advised that players consume specific amounts of CHO before, during, and after matches to maintain performance and recovery, particularly noting that female players may misjudge their energy needs and should adjust their CHO intake accordingly.
Serum ARGS-aggrecan in a phase 2 clinical trial targeting osteoarthritis.
Osteoarthritis Cartilage
November 2024
Objective: To monitor serum concentrations of the aggrecan alanine-arginine-glycine-serine (ARGS) neoepitope in a clinical trial of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 inhibition as disease-modifying therapy of knee osteoarthritis, and to investigate relationships between reduction in ARGS and change in cartilage thickness, knee-related pain and function.
Design: ROCCELLA trial participants received once-daily oral S201086 75, 150 or 300 mg, or placebo, for 52 weeks. Serum was collected at baseline, 4, 12, 28 and 52 weeks, and 2 weeks post-treatment with ARGS measured by an in-house immunoassay.
Objective: To evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis.
Design: ROCCELLA (NCT03595618) was a randomized, double-blind, placebo-controlled, dose-ranging, phase 2 trial in adults (aged 40-75 years) with knee osteoarthritis. Participants had moderate-to-severe pain in the target knee, Kellgren-Lawrence grade 2 or 3 and Osteoarthritis Research Society International joint space narrowing (grade 1 or 2).
Objective: The presence of elevated dopamine (DA) and its major metabolites in the cytosol of neurons has been associated with their vulnerability in Parkinson's disease (PD). Over 99% of the cell's amines are confined to secretory vesicles (SVs), making these structures fundamental in the regulation of cytosolic DA levels. SVs of platelets use similar, if not the same mechanisms to accumulate serotonin in SVs as dopaminergic neurons do to store DA.
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