Publications by authors named "M T Prieto-Sanchez"
Article Synopsis
- The study investigates how polyamine levels during pregnancy are linked to maternal allergies and immune responses in newborns.
- Spermidine and spermine were found to be the main polyamines in both mothers and their newborns, with lower spermine levels associated with maternal allergic conditions, particularly allergic conjunctivitis.
- Higher levels of polyamines in cord blood correlated with an increased number of lymphocytes and reduced production of inflammatory and Th2-related cytokines, suggesting a potential protective effect against allergies in infants.
Background & Aims: Prenatal folate exposure may alter epigenetic marks in the offspring. We aimed to evaluate associations between prenatal exposure to folic acid (FA) in preconception and in utero with cord blood DNA methylation in long interspersed nuclear element 1 (LINE-1) and Alu short interspersed nuclear elements (SINEs) as markers of global DNA methylation levels.
Methods: Data come from 325 mother-child pairs participating in the Nutrition in Early Life and Asthma (NELA) birth cohort (2015-2018).
Introduction: The female reproductive tract harbours unique microbial communities (known as microbiota) which have been associated with reproductive functions in health and disease. While endometrial microbiome studies have shown that the uterus possesses higher bacterial diversity and richness compared to the vagina, the knowledge regarding the composition of the Fallopian tubes (FT) is lacking, especially in fertile women without any underlying conditions.
Methods: To address this gap, our study included 19 patients who underwent abdominal hysterectomy for benign uterine pathology, and 5 women who underwent tubal ligation as a permanent contraceptive method at Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA).
Maternal urinary concentrations of bisphenol A during pregnancy are associated with global DNA methylation in cord blood of newborns in the "NELA" birth cohort.
Sci Total Environ
September 2022
Article Synopsis
- Endocrine disrupting chemicals (EDCs), especially various bisphenols like BPA, can interfere with normal bodily functions and may pose a risk to public health.
- This study investigated the relationship between maternal urinary BPA levels during pregnancy and DNA methylation in newborns, using a sample of 318 mother-child pairs from the NELA birth cohort.
- Findings suggest that higher BPA exposure, particularly in the 24th week of pregnancy, is linked to increased LINE-1 methylation in newborns, especially boys, but the overall impact on global DNA methylation appears minimal and uncertain in biological significance.
Prediction of the mode of delivery using artificial intelligence algorithms.
Comput Methods Programs Biomed
June 2022
Background And Objective: Mode of delivery is one of the issues that most concerns obstetricians. The caesarean section rate has increased progressively in recent years, exceeding the limit recommended by health institutions. Obstetricians generally lack the necessary technology to help them decide whether a caesarean delivery is appropriate based on antepartum and intrapartum conditions.
View Article and Find Full Text PDF