Publications by authors named "M T Obeid"
As photobiomodulation is growing in the dental field the aim of this prospective, two-arm clinical trial was to assess the radiographic changes for chronic periapical bone lesions related to mandibular molars after primary root canal therapy with or without applying Diode laser on soft tissue. The samples were randomly divided into a Laser group and a mock laser (ML) group. Preoperative CBCT images were compared 12 months later with postoperative CBCT to gauge the changes in the volume of the bony lesion by two observers.
View Article and Find Full Text PDFBackground: Vaccines have contributed to the disappearance of various diseases, and almost eradicated others across the world. Studies have shown that in Lebanon a profoundly small percentage of Syrian refugee children were fully immunized by routine vaccination services. Exploring the knowledge, attitudes, and practices of parents towards vaccination is of crucial importance, given the role of parents in children's immunization.
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- The study identifies biomarkers that can differentiate between immune-related cytokine release syndrome (irCRS) and sepsis in oncology patients undergoing immune checkpoint inhibitor therapy.
- The analysis revealed that hepatocyte growth factor (HGF) and ferritin are particularly effective in predicting outcomes related to irHLH and Grade 3 irCRS, with a 100% positive and negative predictive value.
- Patients with severe irCRS who did not respond to corticosteroids showed complete resolution after treatment with tocilizumab (TCZ), highlighting the potential for targeted therapies in these cases.
Silencing c-myc gene by siRNA delivered by cationic niosomes in MCF-7 cells.
J Pharm Pharmacol
November 2024
Objectives: Gene therapy has a strong potential to treat different cancer types cancers with high therapeutic outcomes. c-myc is believed to be responsible for more than 15% of all gene regulation and functions as a transcription factor for proteins essential for cell proliferation. This study aimed to develop niosome nanocarriers to knockdown c-myc expression using anti-c-myc short-interfering RNA (siRNA) in MCF-7 cells.
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- - Gastrointestinal immune-related adverse events (GI irAEs) are a frequent issue linked to immune checkpoint inhibitors (ICIs), impacting various parts of the GI system, including the stomach, liver, and pancreas.
- - A systematic review was conducted using multiple databases, leading to the analysis of 166 studies focused on GI irAEs, examining their incidence, management strategies, and patient outcomes.
- - The review covers different types of GI toxicity related to ICIs, including upper GI (like esophagitis), lower GI (such as colitis), and other rare forms, aiming to provide clinicians with insights for better diagnosis and treatment.