Publications by authors named "M T N Trieu"
To protect healthcare workforce during the COVID-19 pandemic, rigorous efforts were made to reduce infection rates among healthcare workers (HCWs), especially prior to vaccine availability. This study aimed to investigate the prevalence of SARS-CoV-2 infections among HCWs and identify potential risk factors associated with transmission. We searched MEDLINE, Embase, and Google Scholar from 1 December 2019 to 5 February 2024.
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- The study aimed to compare immune responses to a COVID-19 booster vaccination between older adults and younger individuals, focusing on humoral and cellular immunity.
- Researchers found that older adults (average age 86) initially had lower immune responses after earlier vaccinations compared to younger adults (average age 39), but both groups improved their antibody levels after the booster.
- While young adults showed increased cellular immune responses after the booster, older adults did not, and their plasma showed higher levels of certain T cell activation and exhaustion markers, indicating potential immune dysfunction in the elderly.
Article Synopsis
- A study investigated the timing of bivalent mRNA COVID-19 booster vaccinations in highly vaccinated adults, comparing immediate vs. a 3-month delayed administration.
- The findings showed no significant difference in immune response (antibody levels and effectiveness against variants) between the two groups.
- The results suggest that delaying booster shots does not provide any additional benefits in enhancing immunity during the current endemic phase of the virus.
Despite significant advances in understanding acute respiratory distress syndrome (ARDS), mortality rates remain high. The appropriate use of adjunctive therapies can improve outcomes, particularly for patients with moderate to severe hypoxia. In this review, the authors discuss the evidence basis behind prone positioning, recruitment maneuvers, neuromuscular blocking agents, corticosteroids, pulmonary vasodilators, and extracorporeal membrane oxygenation and considerations for their use in individual patients and specific clinical scenarios.
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