A protein corona modulates the function of mineralization-competent matrix vesicles.

Mineralizing cells release a special class of extracellular vesicles known as matrix vesicles (MV), crucial for bone mineralization. Following their release, MV anchor to the extracellular matrix (ECM), where their highly specialized enzymatic machinery facilitates the formation of seed mineral within the MV's lumen, subsequently releasing it onto the ECM. However, how MV propagate mineral onto the collagenous ECM remains unclear.

Impact of charge distribution on the stability of ferroelectric nematic liquid crystals.

This study explores the influence of charge distribution and molecular shape on the stability of ferroelectric nematic liquid crystalline phases through atomistic simulations of DIO molecules. We demonstrate the role of dipole-dipole interactions and molecular shape in achieving polar ordering by simulating charged and chargeless topologies, and analysing positional and orientational pair-distribution functions. The charged DIO molecules exhibit head-to-tail and side-by-side parallel alignments conducive to long-range polar order, whereas the chargeless molecules show no polar ordering.

Human sleep and immunity: The role of circadian patterns.

It is well established that sleep promotes health and welfare. Literature data suggests that sleep is a recurrent resting state that performs multiple biological functions, such as memory consolidation and regulation of glucose, lipid metabolism, energy metabolism, eating behavior, and blood pressure, besides, regulating the immune system. These immunological functions depend on regular sleep and circadian rhythms, as both impact the magnitude of immune responses.

Relationship among depression, fatigue, and sleep after traumatic brain injury: The role of physical exercise as a non-pharmacological therapy.

Traumatic brain injury (TBI) is a burdensome condition frequently associated with an increased risk of psychiatric disorders. Although the exact molecular signaling pathways have not yet been fully defined, the compromised integrity of functional brain networks in regions such as the prefrontal cortex and anterior cingulate cortex has been linked to persistent symptoms, including depression, fatigue, and sleep disorders. Understanding how TBI affects neural physiology enables the development of effective interventions.

Comparison of Sphenoid Sinus Morphology in Bilateral Cleft Lip and Palate and Control Groups: A CBCT Study.

Objective: To investigate and compare the morphology of the sphenoid sinus (SS) in patients with bilateral cleft lip and palate (BCLP) and the control group.

Design: A retrospective comparative study.

Setting: Craniofacial rehabilitation institution.