Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug.

Introduction: Androgenetic alopecia (AGA) is a multifactorial and age-related dermatological disease that affects both males and females, usually at older ages. Traditional hair repair drugs exemplified by minoxidil have limitations such as skin irritation and hypertrichosis. Thus, attention has been shifted to the use of repurposing drugs.

Feasibility and optimal sizing analysis of hybrid PV/Wind powered seawater desalination system: A case study of four ports, Egypt.

This research aims to investigate A novel and complete system consists of hybrid renewable energy farm with high-energy-consuming seawater desalination in fourth locations in Egypt. This paper proposes fuzzy-based multi-criteria decision-making model for optimal sizing of a hybrid PV/Wind/Storage system to power the reverse osmosis (RO) desalination process in order to increase freshwater availability and meet the electric load requirement in selected area. Firstly, according to collected data and cost of electricity (COE) for various renewable energy resources, specific procedures to determining the optimal system design and optimal sizing (solar cell, wind turbine parameter and storage system units) are presented for selected site.

Engineered Porous Beta-Cyclodextrin-Loaded Raloxifene Framework with Potential Anticancer Activity: Physicochemical Characterization, Drug Release, and Cytotoxicity Studies.

Background: Cancer ranks as the second most common cause of mortality as depicted by the World Health Organization, with one in six deaths being cancer-related mortality. Taking the lead in females, breast cancer is the most common neoplasm. Raloxifene, a selective estrogen receptor modulator, has been utilized as a chemotherapeutic agent for the treatment of breast cancer in postmenopausal women.

Application of Box-Behnken design in the optimization and development of albendazole-loaded zein nanoparticles as a drug repurposing approach for colorectal cancer management.

Colorectal cancer (CRC) is the second cancer worldwide representing a major global health challenge. Numerous effective anticancer drugs have been developed in the last decade, yet the problem remains due to their low therapeutic index and nonspecificity. A new anticancer therapeutic paradigm is based on repurposing and nanoformulating drugs.